What happens when you stop Ozempic? How GLP-1 withdrawal affects your health

Ozempic and other

GLP-1 agonists

that are effectively helping people manage obesity have risen in popularity over the years. The weekly injectables can support weight loss up to 20% of the body weight which can be life changing for many given the reduced risk of chronic diseases and a better quality of life. Weighing their miraculous effects on weight loss against unpleasant side effects like stomach pain, nausea, and dizziness and the cost of the drugs, some people choose to quit after reaching their goal weight, hoping the pounds won’t return. However, quitting semaglutide may have its own share of health issues. Here’s what to know.
Withdrawal of Ozempic or other GLP-1 agonists may lead to changes in appetite, blood sugar levels, digestive discomfort and fatigue. The effects could be more jarring if you suddenly stop taking the medication instead of gradually decreasing the doses.

High blood sugar levels

If you were taking the drug for type 2 diabetes, quitting Ozempic can cause spikes in blood sugar levels and you may start experiencing symptoms like excessive thirst, headaches, nausea, fatigue, vomiting, blurry vision and excessive urination.

Weight gain

Ozempic has semaglutide that curbs appetite and make you feel fuller. This reduces the overall calorie consumption as you indulge in fewer snacks. However, many people report the return of voracious appetites upon stopping Ozempic which can lead you to regain some of the weight you lost. In fact, a study published in the journal Diabetes Obesity And Metabolism, going off Ozempic and stopping lifestyle interventions like diet and exercise could lead to regain of up to two-third of the weight lost approximately. Almost half of GLP-1 users with obesity had discontinued their medication one year in, according to research published in JAMA.

Blood pressure and cholesterol levels may shoot up too

Semaglutide withdrawal is also linked to return of risk factors that were earlier reversed by taking weight loss drugs. For instance blood sugar control, reduced blood pressure, lower cholesterol levels, and a decreased risk of cardiovascular diseases that one may have achieved with Ozempic can diminish or disappear, leading to a return of higher blood sugar levels, increased blood pressure, worsened cholesterol profiles, or other risk factors associated with obesity and cardiometabolic conditions.

Lifestyle changes that can help prevent weight regain after Ozempic

Regular exercise: According to a study published in ScienceDirect, physical activity after withdrawing from semaglutide medications can help prevent weight regain.
Drinking loads of water: Drinking water can help you feel full. It can also help you shed calories.
Eat a healthy and balanced diet: Foods rich in fibre and nutrients can nourish your body while keeping off unhealthy weight.
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